The liver is an essential organ for energy metabolism. It is an important place for carbohydrate metabolism. The liver helps you gather energy, converting glucose into storage form and then releasing your backup energy whenever needed. It also contributes to the metabolism of fatty acids and lipoprotein particles in your body. They are helpful to transport fat in your blood, which is required to keep creating cell membranes and give you the raw materials for steroid hormones. Thus, if you lose liver function through extensive damage, your energy metabolism will be at a loss, and you may start losing weight. Moreover, if your liver damage is related to liver cancer, there’s a wasting syndrome called cachexia, leading to significant weight loss.