This is not only one of the most commonly known early signs of liver damage. It is also present in a very late stage of hepatic disease. Jaundice is a yellowish color of the skin and the mucosa surface of the body. Thus, not only will your skin adopt a yellow tone, but it will also be noticeable in the white portion of your eyes. Once again, the cause is related to bilirubin, and the explanation is similar to the one laid down above. Bilirubin has a very strong pigment, and the color of bile is mainly due to this substance. When it is accumulated in the blood and the skin, bilirubin serves as a pigment in both, changing their color. In the skin, you will notice the difference through a yellowish tone known as jaundice.