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- Violent behavior: As the disease advances, personality changes become more profound, and patients may become violent. They could also become very demanding with their relatives and caretakers.
- Loss of speech: They gradually lose their ability to speak or adopt intelligible speech.
- Bowel and urinary incontinence: At a late stage of the disease, patients will require assistance in almost every task. They have frequent episodes of urinary or bowel incontinence. Even moving around the house or in their bed may require assistance.
- Difficulty to swallow: As the nervous system deteriorates, nerve and muscle control becomes impaired. In time, these patients may experience difficulty swallowing and eating.